I used two new XP600 printheads for a few weeks and cleaned them as part of routine maintenance. Following a technician friend's advice, I heated the cleaning solution to break down ink residue.
Initially, the ink flowed well, but over time, the flow weakened, especially in one head, until it was almost completely blocked. I took apart one of them that was heavily clogged and found an undamaged black membrane with no visible damage to any other part as shown in the photo / video below, and suspected the heat was the issue.
The hot cleaning liquid turned the ink into a rubber-like state, causing initial flow but eventual blockage. The second head still has severe clogs in three nozzles that soaking and flushing couldn't fix.

Other reasons not to heat cleaning solution
Nozzle Damage; Sudden temperature changes can expand or deform delicate nozzle components.
Chemical Reactions; Some cleaning solutions may become less effective or even react unpredictably when heated.
Using room-temperature cleaning solution is the safest method to prevent further damage and effectively clear blockages.
Recommended Practices for Cleaning DTF Ink from Epson Printheads
Use recommended cleaning solutions
Always opt for cleaning solutions specifically designed for your printer model and the ink you are using. Manufacturers provide effective solutions that work well at room temperature and do not harm printhead components.
Soak Method
Use a soak method. Allow your printhead to sit in a small amount of cleaning solution for several hours or overnight. This method lets the solution break down clogs without the risks associated with heat. In practice, many users have found this method reduces clogs by as much as 70%.
After soaking, manually flush each nozzle.
Regular Maintenance Schedule
Ideally, clean your printhead after every print job or immediately when you notice poor print quality and in the end of the your printing job.
Test Prints
After cleaning, always run a test print. This quick check will let you know if the printhead is operating correctly. Immediate feedback allows you to decide whether further cleaning is necessary. and it will help to keep the ink flow in the head.
Key Takeaways
Use safe, effective methods and avoid heating cleaning solutions. Follow daily routines to manage your printhead to achieve vibrant, high-quality DTF prints. Proactive care ensures the best results.